NEJM is, if not the most authoritative, among the most authoritative medical journals in the world This article states that combined therapy with T4 and T3 may be an improvement over standard Thyroxine (Synthroid®) treatment for patients with low thyroid. Not all patients benefit from T4 (Synthroid®). Patients who received combination therapy with both T3 and T4 improved mood, and physical wellbeing significantly better than those patients on T4 (Synthroid® alone. No test scores for patients on T4 (Synthroid®) alone showed ANY Improvement.
Florida Center for Hormones & Wellness
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