Effects of Testosterone Administration on Fat Distribution, Insulin Sensitivity, and Atherosclerosis Progression – 2003 – Clinical Infectious Disease

In epidemiological studies, serum total and free testosterone concentrations have been inversely correlated with intra-abdominal fat mass, risk of coronary artery disease, and type 2 diabetes mellitus. Testosterone administration to middle-aged men is associated with decreased visceral fat and glucose concentrations and increased insulin sensitivity. Testosterone infusion increases coronary blood flow. Similarly, testosterone replacement retards…

Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men – 2015 – Journal of Clinical Endocrinology and Metabolism

Aromatase inhibition (blocking the conversion of Testosterone to Estradiol) reduces insulin sensitivity, with respect to peripheral glucose disposal, in healthy men.  16 weeks of aromatase inhibition therapy in men has been shown to increase body fat, particularly in the intraabdominal compartment. Aromatase inhibition results in decreased insulin sensitivity. Suppression of estrogen action in skeletal muscle…