Current Status of Testosterone Replacement Therapy in Men 1999

Benefits of androgen replacement therapy include increased energy, hematocrit, muscle mass, strength and stamina; increased ability to perform more physically demanding tasks; and an overall increase in the sense of wellbeing, confidence and motivation. Bone mineral density is increased by testosterone replacement. Improved libido, sexual function and frequency of erection and ejaculation.  With Injectable Therapy,…

Androgen Deficiency in the Aging Male The Beginning the Middle and the Ongoing 2008

Symptoms relating to low testosterone levels include erectile dysfunction, reduced erectile quality, diminished nocturnal erections, increase in abdominal and visceral adipose tissue. Physical symptoms relating to fatigue, decreased vigor and diminished strength, reduced muscle mass, reduction of lean muscle mass, and decreased in bone mineral density. Sexual symptoms include diminished libido, diminished sexual activity, diminished…

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men 2013

Testosterone deficiency accounted for decreases in lean mass, muscle size, and strength. Estrogen deficiency primarily accounted for increases in body fat; and both contributed to the decline in sexual function. As serum testosterone levels decline, there is a concomitant decline in serum estradiol levels.  And Estradiol deficiency may be important in the pathogenesis of some…

Testosterone: More Is Not Always Better – 2009 – Journal of Clinical Endocrinology and Metabolism

When testosterone aromatization into estradiol is blocked, bone mineral density decreases by 1.7%.  Even though testosterone levels may increase with the use of an aromatization inhibitor such, as anastrozole, the estradiol reduction of more than 20% may lead to negative skeletal effects (decrease in bone mineral density).  Estradiol levels…are a more robust…predictor of fracture risk…

Effects of Testosterone on Fat Distribution 2003

In epidemiological studies, serum total and free testosterone concentrations have been inversely correlated with intra-abdominal fat mass, risk of coronary artery disease, and type 2 diabetes mellitus. Testosterone administration to middle-aged men is associated with decreased visceral fat and glucose concentrations and increased insulin sensitivity. Testosterone infusion increases coronary blood flow. Similarly, testosterone replacement retards…

Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age 1999

Testosterone treatment was followed by a decrease of visceral fat mass. Insulin resistance decreased. Diastolic blood pressure and serum cholesterol decreased with testosterone treatment. Insulin sensitivity improved. Testosterone treatment … gives beneficial effects on well‐being and the cardiovascular and diabetes risk profile, results similar to those observed after hormonal replacement therapy in postmenopausal women. READ…

Testosterone and the Heart 2019

Men with Testosterone deficiency tend to have a portfolio of cardiac risk factors that include Type 2 Diabetes and Metabolic Syndrome.  Testosterone deficiency increases the risk of Cardiovascular disease and the risk of developing Type 2 diabetes and metabolic syndrome.  Many of the key symptoms of low Testosterone are sexual in nature, including erectile dysfunction,…