Testosterone: More Is Not Always Better – 2009 – Journal of Clinical Endocrinology and Metabolism

When testosterone aromatization into estradiol is blocked, bone mineral density decreases by 1.7%.  Even though testosterone levels may increase with the use of an aromatization inhibitor such, as anastrozole, the estradiol reduction of more than 20% may lead to negative skeletal effects (decrease in bone mineral density).  Estradiol levels…are a more robust…predictor of fracture risk…

Effects of Testosterone on Fat Distribution 2003

In epidemiological studies, serum total and free testosterone concentrations have been inversely correlated with intra-abdominal fat mass, risk of coronary artery disease, and type 2 diabetes mellitus. Testosterone administration to middle-aged men is associated with decreased visceral fat and glucose concentrations and increased insulin sensitivity. Testosterone infusion increases coronary blood flow. Similarly, testosterone replacement retards…

Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age 1999

Testosterone treatment was followed by a decrease of visceral fat mass. Insulin resistance decreased. Diastolic blood pressure and serum cholesterol decreased with testosterone treatment. Insulin sensitivity improved. Testosterone treatment … gives beneficial effects on well‐being and the cardiovascular and diabetes risk profile, results similar to those observed after hormonal replacement therapy in postmenopausal women. READ…

A New Independent Risk Factor for Heart Disease 2012

Previously identified risk factor for coronary artery and heart disease were age, low high-density lipoprotein (good cholesterol), and free testosterone.  However, free testosterone may be the strongest predictor of coronary artery disease than other factors such as blood pressure, cholesterol, diabetes, smoking and body mass index (obesity). An overwhelming volume of data shows that higher…

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study – 2011 – European Society of Endocrinology

A previous major summary study evaluating the effect of Testosterone Therapy on Cardiovascular Events, showed Testosterone Therapy safety, because it was not associated with an increased risk of Cardiovascular Disease.  Similar results were also reported in another review that analyzed 51 placebo-controlled studies with follow-up ranging from 3 months up to 3 years.  While higher…