NEJM is, if not the most authoritative, among the most authoritative medical journals in the world This article states that combined therapy with T4 and T3 may be an improvement over standard Thyroxine (Synthroid®) treatment for patients with low thyroid. Not all patients benefit from T4 (Synthroid®). Patients who received combination therapy with both T3…
Investigation of the effect of testosterone replacement therapy (TRT) on depressive symptoms in patients with late-onset testosterone deficiency. Testosterone improves depressive symptoms in most trials, except in patients with major depressive disorder. READ FULL ARTICLE
Oral Progesterone provides endometrial protection…Vaginal Progesterone provides endometrial protection…Transdermal MP does not provide endometrial protection. READ FULL ARTICLE
Estrogen levels are a predictor of Bone Mineral Density in both aging men and post-menopausal women. Age-related bone loss may be the result of Estrogen deficiency not just in postmenopausal women, but also in men. In conclusion: in aging men, estrogen is the dominant sex steroid regulating bone resorption. READ FULL ARTICLE
Men with low estradiol levels are at an increased risk for future hip fracture. Elderly men with low serum testosterone and estradiol have increased risk of mortality, and subjects with low values of both testosterone and estradiol have the highest risk of mortality. READ FULL ARTICLE
Normalization of Testosterone levels after Testosterone Therapy is associated with a significant decrease in the incidence of Atrial Fibrillation. READ FULL ARTICLE
Men with Testosterone deficiency tend to have a portfolio of cardiac risk factors that include Type 2 Diabetes and Metabolic Syndrome. Testosterone deficiency increases the risk of Cardiovascular disease and the risk of developing Type 2 diabetes and metabolic syndrome. Many of the key symptoms of low Testosterone are sexual in nature, including erectile dysfunction,…
There is evidence to suggest that low concentrations of Testosterone are associated with an increased risk of cardiovascular disease in men. When serum Free Testosterone levels are low the risk of carotid artery sclerosis (hardening of the artery) the risk is high. READ FULL ARTICLE
Previously identified risk factor for coronary artery and heart disease were age, low high-density lipoprotein (good cholesterol), and free testosterone. However, free testosterone may be the strongest predictor of coronary artery disease than other factors such as blood pressure, cholesterol, diabetes, smoking and body mass index (obesity). An overwhelming volume of data shows that higher…
Estrogen supplementation in healthy men aged more the 65 years reduces the levels of homocysteine, fibrinogen, and plasminogen activator inhibitor and has a favorable effect on cholesterol, VLDL- C, LDL-C and HDL-C. READ FULL ARTICLE